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This direct transport of extracellular cystine does not take place in hepatocytes, where the reduction of cystine to cysteine occurs mainly in the outer cell membrane as a consequence of GSH efflux (11)

Sertraline (Zoloft) is also an inhibitor at CYP2D6, but it doesnt become potent until you reach the higher dosages, like 150 mg and above

Further knowledge remains on how to translate these results into therapeutic approaches

Although folic acid is readily absorbed thanks to its single glutamate residue, it is not active as a coenzyme: the enzyme dihydrofolate reductase (DHFR) needs to convert it to tetrahydrofolate for further use [ R , R ]