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Big Pharma has lost trust due to overcharging for drugs and overmarking products leading to harm, like Vioxx 20 years ago
Since then, other numerous genetic alterations in SNCA (single-point mutations, duplications, and/or triplication) [39,40,41,42,43,44,45] and other genes ( GBA , PINK1 , LRRK2 , Parkin, or DJ1 , among others) [46,47,48,49] gradually appeared as risk factors of PD early onset and progression, opening up possibilities for the development of genetic models that recapitulate the molecular origin the disease better than the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 6-hydroxydopamine (6-OHDA) neurotoxin ones do [50]
During this period, the patent dance commences within 20 days of aBLA acceptance
& Ross, G., 2010
