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it is also a major NAD + consumer with a lower K m than most NAD + -consuming enzymes 40 and is implicated in the decline of NAD + levels observed during aging and disease 5052
Evidence for glucose/hexosamine in vivo regulation of insulin/IGF-I hybrid receptor assembly
Importantly, food intake did not change, confirming that the mechanism was direct fat mobilization rather than appetite suppression (Heffernan et al., 2001)
