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Hypercortisolism Increased basal plasma concentrations of ACTH and cortisol as well as increased urinary cortisol-to-creatinine ratios are invariably present in dogs with portosystemic shunting.43, 44, 45, 46 Cortisol interferes with the action of arginine-vasopressin at the renal tubule, causing a nephrogenic-type diabetes insipidus

doi: 10.3390/horticulturae9060693

Additional results were obtained in C57BL/6J inbred mice bearing the syngeneic CT-2A high-grade stem cell glioma 32

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