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For chronic conditions requiring ongoing B6 therapy, clinicians aim to find the lowest effective dose

There is agreement that the malabsorption of vitamin B12 can be suspected in people with autoimmune disorders, in patients who have had gastric surgery, in people with a family history of pernicious anemia or with positive test results for serum antibodies against intrinsic factor or parietal cells

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The complete absence of human safety data for neurological applications, particularly long-term use affecting mental health, represents a critical knowledge gap