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Common reported effects in clinical use include mild injection site reactions with subcutaneous administration, occasional digestive changes when taken orally, and rare reports of fatigue or dizziness

For healthy UK adults, the Reference Nutrient Intake is 1.5 micrograms daily, easily obtained through diet

Consumption of vitamin B12 among professional athletes in Poland
Gou and colleagues also found that HAPH was positively correlated with age, metabolic syndrome, male sex, obesity, and hypoxemia
