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In addition, we observed that NADase activity is essentially absent in several tissues from CD38 deficient mice [17]

Water intake was calculated as the difference between the final volume measured and the remaining volume over 24 h

To substantiate the weight-lowering efficacy in another rodent species, Sprague-Dawley rats fed a high-fat high-sugar diet for 4 weeks were treated with once-daily s.c

10.1038/nature06471 [DOI] [PubMed] [Google Scholar] 103.Gessner MA, Werner JL, Lilly LM, Nelson MP, Metz AE, Dunaway CW, et al