glutathione pyruvate dehydrogenase Glutathionylation of complex E2 and inflammatory cytokine production during acute inflammation are magnified by mitochondrial oxidative stress Pyruvate dehydrogenase operates as an

Further, biomarker concentrations are tricky to interpret: Total GSH concentration often fails to accurately reflect redox balance, which is better indicated by the GSH to GSSG ratio, plasma/serum concentrations are often a weak correlate of tissue level (the locus of action), and compartmentalization within cells (cytosol versus mitochondria) adds another layer of complexity often out of grasp in clinical samples [31]

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doi: 10.1021/acs.chemrestox.9b00028 11 CheahI

When saliva production changes, the saliva that remains can feel sticky or ropy rather than thin and slippery