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Description
When glutamate is released from excitatory neurons, it stimulates type I and V metabotropic glutamate receptors (mGluRs) in astrocytes, the activation of which induces elevation of the astrocytic [Ca 2+ ] i , which in turn triggers glutamate release from astrocytes

It might take a minute or two, but the lyophilized powder will fully dissolve into the solution

10.1093/eurheartj/ehn0181 30

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