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Description
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DRD2 downregulation: Chronic dopamine flooding reduces the number and sensitivity of dopamine D2 receptors (DRD2) in the striatum, meaning progressively more Adderall is required to activate the same level of reward

After removal of the cell culture media, the cells were submerged with a fixative, which was prepared as follows: 2.5% glutaraldehyde (Agar Scientific, Stansted, Essex, UK) in 0.15 M HEPES (Fluka, Buchs, Switzerland) with an osmolarity of 670 mOsm and adjusted to a pH of 7.35

These could include hyper-vascular diseases of the eye like diabetic retinopathy and the wet type of macular degeneration
