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The methodology is explicitly described as descriptive rather than causal: 1,778 patients enrolled, 177 respondents, external comparator drawn from 16 tirzepatide publications, internal confidence intervals shown with Wilson methods, and a warning that the comparison does not establish comparative efficacy or safety

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For example, it stimulates the proliferation and differentiation of keratinocytes

Overall, these effects lead to weight loss, increased insulin sensitivity, decreases in visceral fat, and reductions in cardiometabolic risk