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Additionally, although rare, there have been reports linking green tea extract supplementation to liver-related issues, particularly in individuals with sensitive metabolisms or those taking high doses for extended periods (Saha et al., 2024)

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Additionally, a 2016 randomized, placebo-controlled trial in 100 participants with bipolar disorder reported a reduction in the severity of manic episodes with daily supplementation of 1,000 mg omega-3 PUFA for three months (197)

These findings were altered in the HDF group which exhibited increased expression of gluconeogenic genes pepck and g6p with a reduced expression level of pk