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doi: 10.3109/0886022X.2011.618972

Polycyclic aromatic hydrocarbons (PAHs) found in cigarette smoke, for example, have been shown to decrease the activity of P450 enzymes, leading to a decrease in SAMe production and impaired DNA methylation

Hanschmann EM, Godoy JR, Berndt C, Hudemann C, Lillig CH

Optimal gut bacteria means improved digestion, mood, and optimal health