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NRF2 agonist sulforaphane inhibited lipid peroxidation via AMPK/NRF2 pathways, which suppressed ferroptosis and prevented DCM (33)

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Since HFF C57BL/6 mice develop fatty liver, but not NASH, we sought to further explore the impact of GPX1 deficiency on the development of NASH and the associated inflammation and fibrosis in mice fed a CDAA diet for 12 weeks

Although it is well known that leptin plays a central role in regulating energy balance by suppressing food intake and promoting energy expenditure, the existence of leptin resistance in majority of obese individuals hampers the utilization of leptin therapy against these disorders