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When this vasoconstriction occurs, the brain receives less blood flow and therefore less oxygen
This property of PTX is most likely due to its ability to reduce the synthesis of the pro-fibrotic cytokines TGF-1 and PDGF, which are capable of promoting osteogenesis in PD plaque, thus inducing its calcification [21,22,46,62,63,103,104]
Journal of Investigative Dermatology, 135, 1244-1252
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