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The ET-2 protein is encoded by the EDN2 gene that is located on chromosome 1p34.2 and is composed of 6 exons that generate two alternatively spliced mRNAs encoding preproproteins of 178 amino acids (isoform 1) and 145 amino acids (isoform 2)
Encapsulation of ascorbic acid in ethyl cellulose nanoparticles was resulted in enhanced drug stability, increased anti-tyrosinase activity, and therefore improved skin whitening potential (Singh et al., 2023)
One ml aliquot of the supernatant was neutralized with 1.5 ml of 0.5 M phosphate buffers (pH 7.5), then 50 l H 2 O was added
