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"Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC) on a request from the Commission related to L-Carnitine-L-tartrate for use in foods for particular nutritional uses (adopted on 3 November 2003 by written procedure) " The EFSA Journal 19: 1-13

This is particularly crucial when normal glucose metabolism is impaired, a phenomenon frequently observed in neuroinflammatory conditions

Although ALCAR is not a first-line treatment for severe depression, it should be kept in mind for patients with dysthymia, possible cerebrovascular insufficiency, fibromyalgia, or an inability to tolerate prescription antidepressant medications