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Consequently, Zubair et al did not recommend glutathione as a skin-lightening agent.14 In contrast, Weschawalit et al3 reported a statistically significant effect of glutathione as a skin-lightening agent, but this was limited to a group of participants aged older than 40 years who received GSH, a reduced form of glutathione, on the sun-exposed area of the right forearm.3 Arjinpathana et al1 used a Mexameter (Courage+Khazaka Electronic, Kln, Germany) to measure the melanin index as the main output parameter and found that glutathione was most effective on sun-exposed skin.1 In their systematic review, Dilokthornsakul et al15 likewise reported that glutathione might lighten skin tone in sun-exposed areas

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Glutathione peroxidase-1 immunoreactivity in insulin- and glucagon-negative islet cells, shown here, likely represents somatostatin and/or pancreatic polypeptide hormone and ghrelin cells or non-endocrine cells located within the intra-islet vascular region, such as endothelial cells or immune cells