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It was also shown that mice with overexpression of dominant-negative PKD1 exhibited decreases running performance and significantly impaired voluntary running-induced myofiber transformation in skeletal muscle, which confirms that PKD1 plays a crucial role in skeletal muscle remodeling upon physical training [173]

Activation of the endoplasmic reticulum unfolded protein response by lipid disequilibrium without disturbed proteostasis in vivo

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