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The FDA and KMFDS approved a phase III, multicenter, randomized, double-blind, sham-procedure-controlled trial, conducted exclusively in South Korea [166] NCT 04745299, KCT0005954, which did not meet primarily efficacy outcomes [167], though long-term follow-up and safety reporting continues through 2026

However, the exact link between endometriosis and infertility is unknown, and many factors may be involved in this link

Additionally, miR-29c-3p, identified as a novel epigenetic regulatory factor, has been shown to enhance the activity of the ADH6 enhancer, consequently bolstering the expression of the ADH gene cluster, which includes alcohol dehydrogenase 1A (class I), alpha polypeptide (ADH1A), and alcohol dehydrogenase 1B (class I), beta polypeptide (ADH1B) (Chen et al., 2022)