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For example, in AML, LSD1 inhibitors currently in clinical trials can overcome resistance by reshaping the epigenome of CD8 + T cells and enhancing antitumor immunity [253, 254] (Table 2)

Interestingly, the NCT00071799 study reported that MDS patients treated with 5-Aza (75 mg/m 2 subcutaneously) + BSC exhibited prolonged hematological responses and increased RBC IT compared to those receiving standard chemotherapy (cytarabine + anthracycline) + BSC (median OS: 24.5 months vs 16 months) [346,347,348,349,350]

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