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1971 Expected and Observed Values for the Prescription of vitamin B12 in England and Wales A.L

Sometimes a temporary swelling on the injection site occurs

Although raised homocysteine levels might be partly due to a poor vitamin B 12 status, the latter was not related to risk of dementia or Alzheimer's disease in this study (73)

A study conducted in 2016 thus came to the following conclusion: If we had restricted the treatment of symptomatic patients to patients with both low serum levels and elevated metabolite levels, 63% of patients who responded well to the therapy would not have received treatment [] Only 16% of patients with good clinical improvement from vitamin B12 therapy had low serum levels and 54% of patients with good clinical improvement from vitamin B12 therapy had serum levels higher than 300 pg/mL. Some experts thus advise high-dose B12 treatment to treat all known nervous symptoms associated with B12 deficiency