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The periodontal status of indirectly lead-exposed apprentices working in autorepair workshops
(2013) studied serum from 22 FM patients compared with 22 healthy female controls and identified significant alterations in purine metabolism, specifically decreased levels of adenosine, a precursor for ATP synthesis

The immune system itself can produce melatonin, which interacts with IL-2/IL-2R signaling and is regulated differently from pineal-derived melatonin, with NF-B playing distinct roles in this inflammatory regulation
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