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It has been demonstrated that the cAMP response element regulator (CREM) could induce the ICER isoform to promote Th17-cell differentiation, which also enhanced the expression of GLS1, the first enzyme in the Gln catabolic pathway, so that inhibition of GLS1 could improve Th17 differentiation in vitro and in mouse EAE (47)

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Yet additional glycocalyx components, namely hyaluronic acid and its fragments are well documented molecules involved in pathological states (41)

Discussion To the extent of our knowledge, this is the first study to quantify brain GSH, using a validated MRS method (53), and explore relationships between peripheral MMPs, TIMPs, and MPO in participants with PTSD and HC