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In patients with G6DP-deficiency, hemochromatosis, history of kidney stones or chronic kidney disease, or if blood sugar cannot be determined with reliable devices, vitamin C should not be used in higher dosages

Epigeneticmetabolic interplay in cancer stem-like cells One of the most intriguing aspects of cancer stem-like cells biology is the tight coupling between metabolism and epigenetic regulation

Deletion of the insulin receptor in a mouse model showed decreased blood glucose levels in response to IGF-1 (112), whereas in vivo reduction of serum IGF-1 by 80% impaired glucose tolerance (113)

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