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Confirming the significant role of Met35 of A1742 in these observations, when the Met35 residue was substituted by norleucine (as noted above, CH 2 in place of the S-atom of Met), no oxidative damage or neurotoxicity to hippocampal neurons was found (115)

Psychiatry 14:1142608

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Indeed, as demonstrated by DeBerardinis et al , proliferating cells utilize the TCA cycle as the source of not only bioenergetic NADH and FADH 2 equivalents, but also biosynthetic precursors as well