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The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human bloodbrain barrier

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Chemicals NNMT inhibitors and standards for LC/MS/MS studies were purchased from established commercial suppliers or synthesized in-house by established synthetic schemes as described previously.[17] SAM, NA, 1-MQ, 1,8-diMQ, NAD + , and 6-chloro nicotinamide (6-CN) were obtained from Sigma-Aldrich (St