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Human IGF-1 was obtained from GroPep (Theberton, SA, Australia)

In contrast, the positive control group that received AZA showed significant liver and kidney injury, characterized by activation of Kupffer cells and localized hepatocellular necrosis with an influx of inflammatory cells and collagen fiber deposition around the central vein (Figures 11C, D), along with renal tubule epithelial vacuolar degeneration and interstitial edema (Figures 12C, D)

Thus, if left unchecked, it can lead to cytotoxicity and ultimately cell death