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Cell 71 : 765776 Senftleben U, Li ZW, Baud V, Karin M (2001) IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis

However, it should be emphasized that the generalizability of our findings targeting PEX5, which undermines peroxisome biogenesis and integrity, may be limited in diseases with intact peroxisome biogenesis, including adrenoleukodystrophy, in which PEX5 expression and function are conserved and in which pathogenic mechanisms stem from disruptions in specific peroxisomal pathways rather than global peroxisome dysfunction