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Instead of being burned for fuel, these fats accumulate outside the mitochondria, leading to lipotoxicity and further cellular stress

doi: 10.1007/s10545-006-0199-x, PMID: [DOI] [PubMed] [Google Scholar] 41.Salguero Olid A, Blanco Sanchez G, Alonso OA

Other recognized but rare complications of overdose include heart block, pancreatitis, acute renal failure, alopecia, leucopenia, thrombocytopenia, anaemia, optic nerve atrophy and acute respiratory distress syndrome [18,50]

This deficiency is often triggered by heavy exercise, and can also manifest as a result of exposure to cold, infection, emotional distress, and/or fasting [132]