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Providing support for a causal link between a negative energy state and increased Parasutterella abundance, a rat model of obesity, which showed similar Parasutterella relative abundances in animals maintained on HFD and those maintained on normal chow but exhibited a treatment-induced increase in Parasutterella relative abundance, displayed a negative correlation between Parasutterella and body weight 82

The useful observation in this window is simple tolerability whether the chosen route is comfortable and consistent

It is advisable to consult a specialist before starting a new treatment or supplement regimen

The other consistent context in the preclinical literature is a metabolic environment the mouse studies pair the compound with diet/energy-balance conditions rather than testing it in isolation