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Non-response was defined as a less than 50% decrease in serum transaminases within 4 weeks of starting treatment

This was further supported by studies using the partial 5 -GABA A receptor inverse agonist Ro 154,513, by the selective 5 GABA A inverse agonist (5IA-II) (Stephens et al., 2005) and by the use of the 5 -GABA A receptor knockout mice model showing reduced ethanol preference (Boehm II et al., 2004

This indicates no defect in ability to produce GSH from constituents and in fact we observed no decrease in the expression of GSH producing enzymes GCLc/GCLm (Fig