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10.1038/372186a0 Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, et al .: Disruption of IRS-2 causes type 2 diabetes in mice

[DOI] [PubMed] [Google Scholar] 52.Kim S, Benguria A, Lai CY, Jazwinski SM

Mechanistically, folic acid attenuates activation of the NOD-like receptor thermal protein domain-associated protein 3 (NLRP3) inflammasome, thereby suppressing glial activation and neuroinflammation as well as preserving mitochondrial integrity through p53-peroxisome proliferator-activated receptor coactivator 1 (PGC-1) pathway [174]

Studies have also demonstrated that iron overload and lipid peroxidation are key inducers of ferroptosis in the pathophysiology of SCI (Figure 3B)