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particularly, it has a prominent effect on alcohol-lesions (i.e

Garca-Minguilln et al., Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine, Genes Nutr., vol

However, at the same time that folate deficiency was largely eliminated in these populations, the prevalence of intake exceeding the Tolerable Upper Intake Level of folic acid intake (1 mg/d) increased substantially (6, 22), although this was attributed to the concurrent use of supplements and fortified ready-to-eat cereals rather than to fortification alone
