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In more detail, an abnormal cholinergic system regulates and promotes changes in the metabolism of amyloid precursor protein and tau phosphorylation, triggering neurotoxicity, neuroinflammation, and neuronal death

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Nevertheless, according to magnetic resonance physics, at least a fraction of the GBCA-contrast information due to blood vessels is present and partially encoded, in non-contrast structural MRI scans through a non-linear function