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Description
APAP-induced hepatotoxicity is mainly caused by the production of N-acetyl-p-benzoquinone imine (NAPQI), a highly reactive intermediate formed predominantly via the cytochrome P450 2E1 (CYP2E1)
The nature of the reaction varies from enzyme to enzyme, with some P450 enzymes being very specific and others being somewhat more versatile
Additionally, ELISA was performed to quantify secreted IL-6 and TGF- in co-culture media [2]
L.MoralesB.PurgattoE.Egea-FernndezJ
