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The former includes tumor size and multiplicity, presence or absence of portal vein invasion by tumor (PVT), degree of tumor differentiation, serum levels of serum alpha-fetoprotein [1-4] and an immature form of prothrombin called des-gamma carboxy prothrombin or DCP [5], which in turn is associated with increased incidence of PVT [6]

Rather than acting through a single receptor or mechanism, the peptide influences several systems that collectively promote tissue repair and protection

The pentose phosphate pathway provides NADPH, necessary for converting oxidized glutathione (GSSG) back into its reduced form (GSH), which is vital for scavenging reactive oxygen species (ROS)

Nuclear factor erythroid-derived 2-like 2 (NFE2L2, Nrf2) mediates exercise-induced mitochondrial biogenesis and the anti-oxidant response in mice