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Limited Clinical Evidence: Although promising, just a few large-scale clinical trials have been done to confirm long-term effectiveness and safety

For example, a clinical trial involving TXNRD1 inhibitor auranofin has been enrolled in phase I/II clinical trials to treat chronic lymphocytic leukemia, non-small cell lung cancer, and ovarian, peritoneal, and fallopian tube cancers (www.clinicaltrials.gov, trial numbers NCT01419691, NCT01737502, NCT01747798, and NCT03456700)

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After 24 h, cells were expanded into six-well dishes and selected in 1 g ml 1 puromycin for 3 days, then further expanded in nonselective medium