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4-Hydroxypropranolol (0.09-13.25 mg/kg, i.v.) hydrochloride exerts -adrenergic receptor blocking activity and membrane-stabilizing activity, thereby producing dose-dependent cardiovascular effects in normal anesthetized dogs, including decreased heart rate, reduced contractility, diminished aortic blood flow, and prolonged atrioventricular conduction time [1]

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Liquid chromatography-tandem mass spectrometry (LC-MS/MS) The final peptide concentration of each sample was 1 g/L
