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For instance, the Michael acceptor methylene quinuclidinone, the active form of APR-246, was shown to be a potent and direct inhibitor of both TXNRD1 and Glutaredoxin-1 (GRX1) by reacting with the selenocysteine group in both enzymes
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Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis
GE J Port Gastrenterol
