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doi: 10.1017/S0033291703008791

Oxidative Stress as Pathogenesis of Cardiovascular Risk Associated with Metabolic Syndrome

Expression of various MMPs was found to increase in BaP-induced transcriptional activation of MMPs, especially MMP3, is not through activator protein 1 (AP-1) or NF-B, and the expression of MMPs increased the migration and invasion ability of VSMCs in rats (58)

Because IGF-1 is normally found at low levels in MetS and T2D, maybe because of insulin cessation to inhibit IGFBP-1 production by the liver and because of decreased liver IGF-1 secretion by insulin stimulation, as insulin resistance prevails in the liver