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Beyond promoting the release of existing fat stores, research indicates AOD9604 may also help limit the formation of new fat, suggesting a role in reducing fat storage overall rather than only accelerating its breakdown

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By activating both incretin pathways, tirzepatide enhances insulin secretion in a glucose-dependent manner, suppresses glucagon release, delays gastric emptying, and reduces appetite through central nervous system effects

This posits that even though Fragment 176-191 may not directly activate beta-3 adrenergic receptors, the increased number of receptors might amplify the natural lipolytic response to endogenous catecholamines (like adrenaline), which are suggested to engage these receptors directly