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These pleiotropic effects likely contribute to the cardioprotective and cognitive-preserving actions of SGLT2 inhibitors, further supporting the concept that targeting mitochondrial dysfunction can concurrently benefit cardiovascular and neurological outcomes

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Protein S -glutathionylation is an important post-translation modification, providing protection of protein cysteines from irreversible oxidation and, at the same time, serving to transduce a redox signal by changing structure/function of the target protein

The extremely stable mode of administration thus obtained allows better absorption than ordinary preparations