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10.1038/s41467-019-09277-9 Summary Keywords botanical drugs, ferroptosis, neoplasm, phytomedicine, traditional Chinese medicine Citation Tang Y, Zhuang Y, Zhao C, Gu S, Zhang J, Bi S, Wang M, Bao L, Li M, Zhang W and Zhu L (2024) The metabolites from traditional Chinese medicine targeting ferroptosis for cancer therapy

Underlying is an mTORC1/c-Myc pathway of stromal glucose and amino acid metabolism, which causes increased stromal IL-6 production that is required for tumor promotion

Perivascular Adipose Tissue Long-term melatonin treatment normalized the anticontractile effects of perivascular adipose tissue (PVAT) in mice models of accelerated aging

Methods Trial Design REDEFINE 1 (NCT05567796) was a phase 3, double-blind, placebo-controlled, and active-controlled multicenter trial conducted in 22 countries from November 1, 2022, to June 28, 2023