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Subsequently, repair or degeneration occur, which depend on multiple factors such as the type and extent of damage, the immune system, the genetic susceptibility to disc degeneration, which is linked with age, the biomechanical (functional) condition that is created by the injury, and finally the type of treatment: conservative (disc loading) or operative (disc unloading)

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Each addresses inflammation through distinct mechanisms, and emerging evidence suggests their combination may produce synergistic benefits exceeding what either achieves independently