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Regulation of oxidative-stress responsive genes by arecoline in human keratinocytes

A study of the frequency of 1183 T/C polymorphism of SOD2 in Japanese MASH patients revealed a higher incidence of the T/T genotype in the mitochondrial targeting sequence of this gene, resulting in the less effective targeting of Mn-SOD to mitochondria in these patients (Namikawa et al
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