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Its expression is also affected by NF-B [752,753], a transcription factor whose activity depends on frequency rather than amplitude [754,755,756], and this is still rarely recorded

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Overall, a deeper mechanistic understanding reveals that polyphenols are not only act as ROS scavengers but also serve as dynamic modulators of intracellular networks, offering a promising, nuanced approach to counteracting oxidative stress and neuroinflammation in AD pathogenesis