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Supportive of our differentiation model, treatment with vemurafenib produced gene expression changes with time that marked progressive dedifferentiation through our subtype signatures towards the undifferentiated subtype (Figures 2B and 2C)
95 The potential mechanism involves the transdifferentiation of HSCs via the Hippo/Yes-associated protein (YAP) pathway
Biochim Biophys Acta 1863(3):247265
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