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It also promotes the non-amyloidogenic processing of amyloid precursor protein, reducing A peptide production

Activity in primary sensory neurons is essential because local anesthesia relieves acute and chronic pain 3

While beneficial for normal growth, it poses a theoretical risk of accelerating the growth of existing or dormant cancers (for example, prostate, breast, colon) by inhibiting apoptosis (programmed cell death) and driving cell replication

While GR1 encodes a cytosolic, or peroxisomal, form of the enzyme, GR2 , which contains a long N-terminal sequence, encodes a mitochondrial and chloroplastic form