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Despite being dispensable for energy production, mitochondria in neutrophils remain functionally intact, suggesting that neutrophils might opt for the mitochondrial glutaminolysis pathway as an alternative means of supplementing NADPH during ROS generation (Furukawa et al., 2000) (Table 3)
Consequently, it is possible that in NO deficient diseases, there is an overproduction and accumulation of O 2 - that lead to development of oxidative stress both in tissues and organs [117]
[DOI] [PubMed] [Google Scholar] 109.Holmay M.J., Terpstra M., Coles L.D., Mishra U., Ahlskog M., z G., Cloyd J.C., Tuite P.J
